Nichijou follows the everyday lives of various people in the town of Tokisadame, mainly focusing on the energetic Yūko Aioi, the bright and cheerful Mio Naganohara, the quiet and deadpan Mai Minakami, the anxious robot Nano Shinonome, her eight-year-old creator the Professor, and a talking cat named Sakamoto, along with an ensemble cast of characters. Random and/or outlandish events regularly occur throughout the series, mainly through the mundane situations each character undergoes.